Arsenic Health Effects Research

Cancer Studies	Metabolism of Arsenic	Molecular Epidemiology
Risk Assessment	Skin Lesions	Vascular Disease

Cancer Studies

Smith AH and Smith MM. Arsenic drinking water regulations in developing countries with extensive exposure. Toxicology 2004 May 20; 198(1-3):39-44. [PDF]

Bates MN, Rey OA, Biggs ML, Hopenhayn C, Moore LE, Kalman D, Steinmaus C, Smith AH. Case-control study of bladder cancer to arsenic in Argentina. Am J Epidemiol 2004 Feb; 159(4): 381-9. [PDF]

Steinmaus C, Yuan Y, Bates MN, Smith AH. Case-control study of bladder cancer and drinking water arsenic in Western United States. Am J Epidemiol 2003 Dec 15; 158(12): 1193-1201. [PDF]

Moore LE, Smith AH, Eng C, Sandy D, Kalman D, Bhargava V, Chew K, Ferreccio C, Rey OA, Hopenhayn C, Biggs ML, Bates MN, Waldman FM. P53 Alterations in bladder tumors from arsenic and tobacco exposed patients. Carcinogenesis. 2003 Nov;24(11):1785-1791. [PDF]

Moore LE, Smith AH, Eng C, Kalman D, DeVries S, Bhargava V, Chew K, et al. Arsenic-related chromosomal alterations in bladder cancer. JNCI, 94: 1688-96, 2002. [PDF]

Ferreccio C, González C, Milosavjlevic V, Marshall G, Sancha AM, and Smith AH. Lung cancer and arsenic concentrations in drinking water in Chile. Epidemiology, 11: 673-79, 2000. [PDF]

Steinmaus, C, Nuñez S, and Smith AH. Diet and bladder cancer: a meta-analysis of six dietary variables. Am J Epidemiol, 151: 693-702, 2000. [summary]

Steinmaus C, Moore LE, Hopenhayn-Rich C, Biggs ML, and Smith AH. Arsenic in drinking water and bladder cancer. Cancer Invest, 18: 176-84, 2000.

Smith AH, Biggs ML, Moore LE, Haque R, Steinmaus C, Chung J, Hernandez AL, and Lopipero P. Cancer risks from arsenic in drinking water: implications for drinking water standards. In: W Chappell, CO Abernathy and RL Calderon (eds.): Arsenic esposure and health effects: proceedings of the Third International Conference on Arsenic Exposure and Health Effects, July 12-15, 1998, San Diego, California. Oxford: Elsevier Science, Ltd., pp. 191-99, 1999. [summary]

Smith AH, Goycolea M, Haque R, and Biggs ML. Marked increase in bladder and lung cancer mortality in a region of Northern Chile due to arsenic in drinking water. Am J Epidemiol, 147: 660-9, 1998. [summary]

Hopenhayn-Rich C, Biggs ML, Smith AH. Lung and kidney cancer mortality associated with arsenic in drinking water in Cordoba, Argentina. Int J Epidemiol. 27: 561-69. 1998 [PDF]

Brown KG and Beck BD. Arsenic and bladder cancer mortality [letter; comment] Epidemiol, 7: 557-8, 1996. [No abstract available]

Hopenhayn-Rich C, Biggs ML, Fuchs A, Bergoglio R, Tello E, Nicolli H, Smith AH. Bladder cancer mortality associated with arsenic in drinking water in Argentina. Epidemiol. 7:117-124. 1996 [summary]

Bates MN, Smith AH, Cantor KP. Case-control study of bladder cancer and arsenic in drinking water. Am J Epidemiol. 141: 523-30. 1995 [summary]

Smith AH, Hopenhayn-Rich C, Biggs ML, Moore L, Dale J, Warner M, Bates M, and Engel R. Epidemiological study designs to address potential high bladder cancer risks from arsenic in drinking water. In: Chappell WR, Abernathy CO, Cothern CR, eds. Arsenic: Exposure and Health Northwood: Science and Technology Letters: 109-17, 1994. [summary]

Hertz-Picciotto I and Smith AH. Observations on the dose-response curve for arsenic exposure and lung cancer. Scand J Work Environ Health, 19: 217-26, 1993. [summary]

Engel RR and Receveur O. Re: Arsenic ingestion and internal cancers: a review [letter] Am J Epidemiol, 138: 896-7, 1993. [No abstract available]

Smith AH, Hopenhayn-Rich C, Bates MN, Goeden HM, Hertz-Picciotto I, Duggan HM, Wood R, Smith MT, and Kosnett MJ. Cancer risks from arsenic in drinking water. Environ Health Perspect, 97: 259-67, 1992. [PDF]

Bates MN, Smith AH, Hopenhayn-Rich C. Arsenic ingestion and internal cancers: a review. Am J Epidemiol. 135:462-76. 1992 [PDF]

Hertz-Picciotto I, Smith AH, Holzman D, Lipsett M, Alexeef G. Synergism between occupational arsenic exposure and smoking in the induction of lung cancer. Epidemiol. 3:23-31. 1992 [summary]

Frost F, Harter L, Milham S, Royce R, Smith AH, Hartley J, Enterline P. Lung cancer among women residing close to an arsenic-emitting copper smelter. Arch Env Health. 42:148-52. 1987 [summary]

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Metabolism of Arsenic

Hopenhayn-Rich C, Biggs ML, Kalman D, Moore LE, Smith AH. Arsenic methylation patterns before and after changing from higher to lower concentrations of arsenic in drinking water. Environ Health Perspect. 1996 Nov;104(11):1200-7. [HTML]

Chung JS, Kalman DA, Moore LE, Kosnet, MJ, Arroyo AP, Beeris M, Mazumder DN, Hernandez AL, and Smith AH. Family correlations of arsenic methylation patterns in children and parents exposed to high concentrations of arsenic in drinking water. Environ Health Perspect, 110: 729-33, 2002. [PDF]

Hopenhayn-Rich C, Biggs ML, Smith AH, Kalman D, Moore LE. Methlyation study in a population environmentally exposed to high arsenic water. Environ Health Perspect. 1996 Jun;104(6):620-8. [HTML]

Hopenhayn-Rich C, Smith AH, Goeden H. Human studies do not support the methylation threshold hypothesis for the toxicity of inorganic arsenic. Env Res. 60:161-77. 1993 [summary]

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Molecular Epidemiology

Moore, LE, Smith AH, Hopenhayn-Rich C, Biggs ML, Kalman DA, Smith MT. Decrease in bladder cell micronucleus prevalence after intervention to lower the concentration of arsenic in drinking water. Cancer Epidemiol Biomark and Prev. 6:1051-6. 1997 [summary]

Moore LE, Smith AH, Hopenhayn-Rich C, Biggs ML, Kalman DA, Smith MT. Micronuclei in exfoliated bladder cells among individuals chronically exposed to arsenic in drinking water. Cancer Epidemiol Biom & Prev. 6:31-6. 1997 [summary]

Biggs ML, Kalman DA, Moore LE, Hopenhayn-Rich C, Smith MT, Smith AH. Relationship of urinary arsenic to intake estimates and a biomarker of effect, bladder cell micronuclei. Mut Res. 386:185-95. 1997 [summary]

Moore LE, Smith AH, Eng C, Kalman D, DeVries S, Bhargava V, Chew K, Moore D 2nd, Ferreccio C, Rey OA, Waldman FM. Arsenic-related chromosomal alterations in bladder cancer. J Natl Cancer Inst. 2002 Nov;94(22):1688-96. [PDF]

Moore L, Wiencke J, Eng C, Zheng S, and Smith AH. Evaluation of buccal cell collection protocols for genetic susceptibility studies. Biomarkers, 6: 448-54, 2001. [PDF]

Moore L, Warner ML, Smith AH, Kalman D, Smith MT. Use of the fluorescent micronucleus assay to detect the genotoxic effects of radiation and arsenic in human exfoliated epithelial cells. Env Mol Mutagen. 27:176-84. 1996 [summary]

Moore L, Smith AH, Hopenhayn-Rich C, Biggs ML, Warner ML, Kalman D, Smith MT. Increased bladder cell micronuclei found in two populations environmentally exposed to arsenic in drinking water. Clin Chem. 41:1915-17. 1995 [summary]

Warner M, Moore L, Smith MT, Kalman D, Fanning E, Smith AH. Increased micronuclei in exfoliated bladder cells of persons who chronically ingest arsenic contaminated water in Nevada. Cancer Epidemiol Biom & Prev. 3:583-90. 1994 [summary]

Smith AH, Hopenhayn-Rich C, Warner M, Biggs ML, Moore L, Smith MT. Rationale for selecting exfoliated bladder cells micronuclei as potential biomarkers for arsenic genotoxicity. J Toxicol Env Health. 40: 223-34. 1993 [summary]

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Risk Assessment

Wright C, Lopipero P, and Smith AH. Meta-analysis and Risk Assessment. In: Topics in Environmental Epidemiology Eds. Steenland K and Savitz DA: Oxford University Press, 1996. [summary]

Smith AH, Hopenhayn-Rich C, Biggs ML, Kalman D. Re: Arsenic risk assessment. [letter; comment]. Environ Health Perspect. 1995 Jan;103(1):13-7. [HTML]

Smith AH, Hopenhayn-Rich C, Bates MN, Goeden HM, Hertz-Picciotto I, Duggan HM, Wood R, Smith MT, Kosnett MJ. Cancer risks from arsenic in drinking water. Env Health Persp. 97:259-67. 1992 [PDF]

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Skin Lesions

Haque R, Mazumder DN, Samanta S, Ghosh N, Kalman D, Smith MM, Mitra S, Santra A, Lahiri S, Das S, De BK, Smith AH. Arsenic in drinking water and skin lesions: dose-response data from West Bengal, India. Epidemiology. 2003 Mar;14(2):174-82. [PDF]

Smith AH, Arroyo AP, Guha Mazumder DN, Kosnett MJ, Hernandez AL, Beeris M, Smith T, Moore LE. Arsenic-induced skin lesions among Atacameño people in northern Chile despite good nutrition and centuries of exposure. Environ Health Perspect. 2000 Jul;108(7):617-20. [HTML]

Mitra SR, Mazumder DN, Basu A, Block G, Haque R, Samanta S, Ghosh N, Smith MM, von Ehrenstein OS, Smith AH. Nutritional factors and susceptibility to arsenic-caused skin lesions in West Bengal, India. Environ Health Perspect. 2004 Jul;112(10):1104-9.
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Guha Mazumder DN, Haque R, Gosh N, De BK, Santra A, Chakraborty D, Smith AH. Arsenic levels in drinking water and the prevalence of skin lesions in West Bengal, India. Int J Epidemiol. 27:871-77. 1998 [PDF]

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Vascular Disease

Engel RR, Smith AH. Arsenic in drinking water and mortality from vascular disease: an ecologic analysis in 30 U.S. counties. Arch Environ Hlth. 49: 418-27. 1994 [summary]

Engel RR, Hopenhayn-Rich C, Receveur O, Smith AH. Vascular effects of chronic arsenic exposure: a review. Epidemiol Rev. 16:184-209. 1994 [summary]

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University of California, Berkeley ~ School of Public Health ~ 140 Warren Hall MC7360 ~ Berkeley, CA 94720-7360

Telephone: 510/843-1736 ~ Facsimile: 510/843-5539 ~ E-mail: asrg@berkeley.edu