|
|
|
|
|
|
|
|
|
|
|
|
|
- Provided substantive evidence (from ecological studies
conducted in Argentina and Chile) that arsenic is a potent cause of human
bladder cancer and lung cancer.
- Showed that epidemiological and human experimental data
do not support the hypothesis that methylation protects against low dose
arsenic effects.
- Showed that with exposure to water containing around
600 ug/L of arsenic, 1 in 10 adult deaths may be due to arsenic-caused
cancers, one of the highest environmental cancer risks ever reported in a
large population.
- Identified a dose-response relationship between arsenic
exposure and bladder cell micronuclei, a genotoxic marker of effect, and
changes in the frequency of micronuclei after exposure to arsenic is
reduced.
- Identified the dose-response relationship between
arsenic concentration in well water in India and the occurrence of
keratoses and hyperpigmentation.
- Completed two bladder cancer case-control studies, one
in Argentina and one in California/Nevada, showing modest increases in
bladder cancer related to potential exposure to arsenic in wells, but only
in smokers.
|
University
of California, Berkeley ~ School of Public Health ~ 50 University Hall MC7360
~ Berkeley, CA 94720-7360 |
Telephone:
510/843-1736 |