Table S2.  Odds Ratios of Type 2 Diabetes Mellitus and Urine Arsenic Concentrations:

Odds Ratios of Type 2 Diabetes Mellitus and Urine Arsenic Concentrations Including Results Adjusted for Urine Creatinine

No.

Unadjusted

Adjusted^a

Adjusted^b

Cases

Control

OR

95% CI

OR

95% CI

OR

95% CI

Total Arsenic

£20^th percentile (£3.5 µg/L)

21

141

1

ref

1

ref

1

ref

≥80^th percentile (≥18.3 µg/L)

17

142

0.8

0.41-1.59

0.88

0.39-1.97

0.9

0.35-2.34

Lower tertile (£5.2 µg/L)

36

232

1

ref

1

ref

1

ref

Middle tertile (5.3-11.8 µg/L)

32

230

0.9

0.54-1.49

0.87

0.48-1.55

0.87

0.47-1.61

Upper  tertile (>11.8 µg/L)

30

235

0.82

0.49-1.38

0.76

0.42-1.39

0.76

0.37-1.56

Arsenobetaine

Below detection^c (£0.3 µg/L)

42

217

1

ref

1

ref

1

ref

≥80^th percentile (≥6.2 µg/L)

15

142

0.55

0.29-1.02

0.59

0.29-1.19

0.59

0.29-1.22

Lower tertile (£0.3 µg/L)

42

217

1

ref

1

ref

1

ref

Middle (0.4-2.2 µg/L)

29

246

0.61

0.37-1.01

0.68

0.38-1.21

0.68

0.38-1.22

Upper (>2.2 µg/L)

27

234

0.6

0.36-1.00

0.62

0.34-1.13

0.62

0.34-1.15

Estimated Inorganic Arsenic

£20^th percentile (£2.7 µg/L)

20

142

1

ref

1

ref

1

ref

≥80^th percentile (≥11.9 µg/L)

22

139

1.12

0.59-2.15

1.15

0.53-2.50

1.4

0.53-3.69

Lower tertile (£4.1 µg/L)

36

227

1

ref

1

ref

1

ref

Middle tertile (4.2-8.5 µg/L)

29

238

0.77

0.46-1.30

0.63

0.34-1.15

0.67

0.35-1.29

Upper tertile (>8.5 µg/L)

33

232

0.9

0.54-1.49

0.98

0.53-1.80

1.13

0.52-2.48

Dimethylarsonic acid (DMA)

£20^th percentile (£1.9 µg/L)^d

15

111

1

ref

1

ref

1

ref

≥80^th percentile (≥7.0 µg/L)

21

146

1.06

0.53-2.16

1.05

0.45-2.44

1.13

0.42-3.07

Lower tertile (£2.7 µg/L)

35

227

1

ref

1

ref

1

ref

Middle tertile (2.8-5.0 µg/L)

37

252

0.95

0.58-1.56

1.02

0.57-1.82

1.05

0.56-1.95

Upper tertile (>5.0 µg/L)

26

218

0.77

0.45-1.33

0.82

0.43-1.57

0.86

0.40-1.84

Abbreviations: CI, confidence interval; No., number; OR, odds ratios; ref, reference group

^aAdjusted for sex, age, ethnicity, education, body mass index, serum cotinine, and current use of hypertension medications.

^bAdjusted for sex, age, ethnicity, education, body mass index, serum cotinine, current use of hypertension medications and urine creatinine (in ug/L).

cThe detection limit was used rather than the 20^th percentile since > 20% of people had arsenobetaine concentrations below detection.

^dThis group contains fewer than 159 subjects (the 20^th percentile) since a large number of subjects had DMA levels of 2 µg/L and were assigned to the 20-80^th percentile group.

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